[HTML][HTML] An early and massive wave of germinal cell apoptosis is required for the development of functional spermatogenesis
I Rodriguez, C Ody, K Araki, I Garcia, P Vassalli - The EMBO journal, 1997 - embopress.org
I Rodriguez, C Ody, K Araki, I Garcia, P Vassalli
The EMBO journal, 1997•embopress.org… Thus, the salient notion emerging from the various observations and correlations made in
the present work is that of a peculiar early apoptotic wave, occurring in the testicular germ
line and which is essential for the development of normal adult spermatogenesis. This leads
to the discussion of the following questions: when is this physiologically critical apoptotic
wave involving male germ cells taking place? How is it regulated? How can a defect in a
temporary process result in permanent impairment of … In conclusion, the early apoptotic …
the present work is that of a peculiar early apoptotic wave, occurring in the testicular germ
line and which is essential for the development of normal adult spermatogenesis. This leads
to the discussion of the following questions: when is this physiologically critical apoptotic
wave involving male germ cells taking place? How is it regulated? How can a defect in a
temporary process result in permanent impairment of … In conclusion, the early apoptotic …
Results
Male transgenic mice expressing Bcl2 or overexpressing BclxL in their germinal cells are sterile and display marked alterations in the late stages of spermatogenesis
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